Fang Yu, PhD, RN, GNP-BC, FGSA, FAAN

Long-Term Care Professor, School of Nursing

Fang Yu

Contact Info

yuxxx244@umn.edu

Office Phone 612-624-5435

Fax 612-625-7180

Office Address:
6-195B Weaver-Densford Hall

Mailing Address:
School of Nursing
University of Minnesota
5-140 Weaver-Densford Hall
308 Harvard Street SE
Minneapolis, MN 55455

Long-Term Care Professor, School of Nursing

Minnesota Center for Gerontological Nursing Excellence (MnCGNE)


PhD, University of Pennsylvania (Nursing), 1999-2003

MSN, University of Pennsylvania (Gerontological Nurse Practitioner), 1999-2002

John A. Hartford Foundation Building Academic Geriatric Nursing Capacity Postdoctoral Fellow, State College (Gerontology and Nursing), 2004-2006; BM, Beijing Medical University, Beijing, China (Nursing), 1991-1996

Summary

Professional Associations

  • Co-operative Membership:
    Adult and Gerontological Health
  • Center Membership:
    Center on Aging
    Center for Aging Science and Care Innovation
    Minnesota Hartford Center of Gerontological Nursing Excellence
  • Professional Organizations
    American Nurses Association/Minnesota Nurses Association
    International Society to Advance Alzheimer’s Research and Treatment
    Midwest Nursing Research Society
    The Gerontological Society of America

Research

Research Summary/Interests

Using nonpharmacological interventions to prevent and treat Alzheimer’s disease; aerobic exercise and cognitive training in older adults with subjective cognitive decline, mild cognitive impairment (MCI), or Alzheimer’s disease; technology-based interventions; imaging- and blood-based biomarkers for cognitive decline; clinical trials.

Research Funding Grants

Grants and Contracts - External Sources

Role: Consultant
PI: Qiaoqin Wan
National Natural Science Foundation of China (#81871854)
The Impact of Exercise Interventions on Cognition and its Mechanisms of Action
1/1/2019 – 12/31/2022
¥570,000

Role: Co-investigator
PI: Danni Li
National Institute on Aging (1R01AG059654-01)
Blood biomarkers as Surrogate Endpoints of Treatment Responses to Aerobic Exercise and/or Cognitive Training in Amnestic Mild Cognitive Impairment
8/1/2018 – 5/30/2022
$1.93 million

Role: Co-Investigator
PI: Danni Li
National Institute on Aging (1R21AG059068)
Hydroxysphingolipids as a Pathological Mechanism and Plasma Biomarkers of Physical
Function Decline in Older Adults
7/1/2018 – 5/31/2020
$451,528

Role: Principal Investigator (Co-PI: Feng Vankee Lin)
National Institute on Aging (5R01AG055469-01A1)
Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training in MCI (The ACT Trial)
9/15/2017 – 5/31/2022
$3.67 million
(Administrative Supplement, 3R01AG055469-02S1, 6/1/2018 – 5/31/2019, $153,963)

Role: Principal Investigator (Co-PI: Tom Plocher)
National Institute on Aging Small Business Innovation Research (1R44AG055176-01)
Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer’s Disease in at-risk Older Adults
9/17/2017 – 12/31/2019
$1.15 million

Role: Consultant
PI: Shaomei Shang
National Natural Science Foundation of China (81672241)
Research of the Development and Mechanism of the Community-based Intervention model on Elderly Patients with Knee Osteoarthritis
1/1/2017 – 12/30/2020
¥782,280 ($130,000)

Role: Principal Investigator
National Institute on Aging (5R01AG043392-01A1)
Aerobic Exercise in Alzheimer’s Disease: Cognition and Hippocampal Volume Effects
8/1/2013 – 4/30/2019
$3.04 million

Role: Principal Investigator
National Institute on Aging (3R01AG043392-03S1)
Aerobic Exercise in Alzheimer’s Disease: Cognition and Hippocampal Volume Effects (Administrative Research Supplement to Promote Diversity in Health-related Research)
9/1/2016 – 4/30/2018
$119,019

Role: Co-Investigator
PI: Dan Klassen
National Institute on Aging (9R44AG053923-02)
Memory Matters: A Mobile Aid to Stimulate Reminiscing in Persons with Memory Loss
5/15/2016 – 5/31/2018
$1,385,470

Role: Co-Investigator
PI: Danni Li
Alzheimer’s Association (NIRG-15- 362393)
Vascular Biomarkers to Predict Response to Exercise in Alzheimer’s Disease
12/1/2015 – 11/30/2017
$99,999

Role: Principal Investigator
Minnesota Board on Aging (333-16- SDEM-033/PO41518)
Building a Workforce to Provide Exercise to People with Alzheimer’s Disease: The FIT-AD Certification Program
1/1/2016 – 6/30/2017
$98,000

Role: Co-investigator
PI: Tom Plocher
National Institute on Aging (R43AG049548-01A1)
Creating Objects with 3D Printers to Stimulate Reminiscing for Memory Loss
9/1/2015 – 8/31/2016
$224,944

Role: Co-investigator
PI: Julia Johnson
HealthPartners Foundation
Cognition Linked to Endurance & Vigorous Exercise Research in Parkinson’s Disease
(The CLEVER - PD Pilot Study)
8/1/2014 – 12/31/2015
$35,000

Role: Principal Investigator
BrightFocus ® Foundation (AHAF A2009344)
Feasibility of Aerobic Exercise in Alzheimer’s Disease
04/01/2009 – 01/31/2012
$154,000

Role: Scholar
PI: Waite, Linda
The NIH National Social Life, Health, and Aging Project
The Interplay of Factors, Cognition, and Critical Healthcare Events
01/01/2007 – 07/31/2008
$1,500

Role: Scholar
NIH K12 Career Development Award (RR023247-04)
Promoting Cognitive and Functional Independence in Older Adults with Dementia through Aerobic Exercise
03/15/2007 – 07/31/2010
$351,000

Role: Principal Investigator
American Nurses Foundation (ANF grant 2005102)
The Effect of Aerobic Fitness Exercise on Executive Functioning and Function in Community-dwelling Persons with AD
11/01/2005 – 07/31/2007
$4,998

Role: Principal Investigator
John A. Hartford Foundation
Building Academic Geriatric Nursing Excellence (BAGNC) Clair M. Fagin Post-doctoral Fellowship (JAH 04-201)
Promoting Function in Older Adults with Dementia
09/01/2004 – 08/31/2006
$100,000

Role: Principal Investigator
University of Pennsylvania School of Nursing Frank Morgan Jones Research Fund
Sigma Theta Tau International – Xi Chapter
Effectiveness of Comprehensive Ambulatory Outpatient Rehabilitation for Cognitively Impaired Elders
01/01/2002 – 07/31/2003
$2,500
$1,500


Grants and Contracts – University of Minnesota Sources

Role: Principal Investigator (Co-PI: Lin Yee Chen)
Academic Health Center (FRD 17.20)
Moderate-Intensity continuous training and high-intensity interval training in reducing atrial fibrillation burden
11/1/2017 – 10/31/2019
$200,000

Role: Principal Investigator
Academic Health Center Global Health Seed Grant
Factors Associated with Longevity in Guangxi, China
10/1/2016 – 9/30/2017
$25,000

Role: Co-Investigator
PI: Kris Talley
Role: University of Minnesota School of Nursing Foundation
Adherence to Non-Group Based Exercise Interventions in Community-Dwelling Older Adults: Systematic Review and Meta-Analysis
12/1/2015-12/31/2016
$3,000

Role: Co-investigator
PI: Priscila Gibson
University of Minnesota Driven to Discovery State Fair Program
Intergenerational Grandparenting in Minorities: Effects on Cognition and Physical Function
2/24/2015 – 9/7/2015

Role: Awardee
University of Minnesota Office of International Programs
Invited Speaker at the International Conference: Best Practice in Dementia Care, Stavanger, Norway
6/2/2010 – 6/13/2010
$932

Role: Principal Investigator
University of Minnesota Academic Health Center (Seed Grant 2009-40)
Validating Clinical Measures of Executive Function in U.S. Veterans with Dementia
07/01/2009 – 06/30/2011
$25,000

Publications

Publications

Peer-reviewed Journal Articles (*Data-based; § Mentee)

  1. Li, D., Huang, F., Zhao, Y., Villata, P., Griffin, T.J., Zhang, L., Li, L.,† & Yu, F.† (accepted). Plasma lipoproteome in Alzheimer’s disease: A proof-of-concept study. Clinical Proteomis.* †Equal contributions.
  2. Yu, F. (2018). The development and evolvement of the Doctor of Nursing Practice in the U.S. Chinese Nursing Education, 15(6). DOI: 10.3761/j.issn.1672-9234.2018.06.
  3. Yu, F., Chen, Y.†, Mathiason, M.A.†, Wan, Q., Lin, F.V. (accepted). Cognitive and physical factors affecting daily function in Alzheimer’s disease: A Cross-Sectional Analysis. Nursing and Health Sciences.* †Equal contributions.
  4. Wan, Q., Li, Z., Zhou, W., Shang, S.; Yu, F. (accepted). Work engagement and its predictors in a large sample of registered nurses in Chinese hospitals. Nursing and Health Sciences.* §
  5. Wang, J., Maxwell, C.A.; Yu, F. (accepted). Biological processes and biomarkers related to frailty in older adults: A state-of- art literature review. Biological Research for Nursing. §
  6. Li, D., Misialek, J.R., Huang, F., Windham, B.G., Yu, F., Alonso, A. (accepted). Independent Association of plasma hydroxysphingomyelins with physical function in the Atherosclerosis Risk in Communities (ARIC) Study. Journal of Gerontology: Medical Sciences.* §
  7. Yu, F., Vock, D., Barclay, T (accepted). Executive Function: Responses to Aerobic Exercise in Alzheimer’s Disease. Geriatric Nursing. DOI:10.1016/j.gerinurse.2017.09.005. NIHMS907342. PMID: 29031520*
  8. Zhang, R., Simon, G., Yu, F. (2017). Advancing Alzheimer’s Research: A review of big data promises. International Journal of Medical Informatics, 106, 48-56. https://doi.org/10.1016/j.ijmedinf.2017.07.002
  9. Yu, F., Greimel, S., Kaitlin, K., Wyman, J.F. (2017). Strategies to engage older adults with behavioral and psychological symptoms of dementia in exercise: A multiple case study. Applied Nursing Research, 36, 77-80. https://doi.org/10.1016/j.apnr.2017.05.002.*
  10. Bronas, U.G., Salisbury, D., Kelly, K., Leon, A., Chow, L.S., Yu, F. (2017). Determination of aerobic capacity via cycle ergometer exercise testing in Alzheimer’s disease. Alzheimer’s Disease and Other Dementias, 32(8): 500-508. doi:10.1177/1533317517720065. Epub 2017 Jul 18. PMID: 28718297.*
  11. Salisbury, D., Yu, F. (accepted). Aerobic fitness and cognitive changes after exercise training in Alzheimer’s disease. Journal of Exercise and Clinical Psychology.*
  12. Li, D., Yu, F. (2017). Peripheral inflammatory biomarkers and cognitive decline in older adults with and without AD: A systematic review. Journal of Gerontological Nursing, 43(12), 53-60. §
  13. Ahn, S., Chen, Y., Bredow, T., Cheung, C., Yu, F. (2017) Effects of non-pharmacological treatments on quality of life in Parkinson’s disease. Journal of Parkinson’s Disease and Alzheimer’s Disease, 4(1), 10. §
  14. Shah, K.^, Lin, F.V.^, Yu, F., McMahon, J.M. (2017). Activity engagement and physical function in old age sample. Archives of Gerontology and Geriatrics, 69, 55-60. http://doi.org/10.1016/j.archger.2016.11.007. NIHMS832240; PMC5217742.* (^equal contribution)
  15. Li, D., Tsai, M., Li, L., Vock, D., Yu, F. (2016). Vascular Biomarkers to Predict Response to Exercise in Alzheimer’s Disease: Study Protocol. BMJ Open, 6:e011054. DOI: 10.1136/bmjopen-2016- 011054. PubMed PMID: 28039287; PubMed Central PMCID: PMC5223628. §
  16. Yu, F., Vock, D., Demorest, S. L. (2015). Testing a modified perceived exertion scale for Alzheimer’s disease. PsyCh Journal, 4, 38-46. DOI: 10.1002/pchj.82.*
  17. Yu, F., Thomas, W., Nelson, N. W., Bronas, U. G., Dysken, M., Wyman, J. F. (2015). Impact of 6-month aerobic exercise on Alzheimer’s symptoms, Journal of Applied Gerontology, 34(4), 484-500. DOI: 10.1177/0733464813512895.*
  18. Yu, F., Bronas, U.G., Konety, S., Nelson, N.W., Dysken, M., Jack Jr., C., Wyman, J.F.,; Vock, D (2014). Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer’s disease: Study protocol of a randomized controlled trial (The FIT-AD Trial). The Trials Journal, 15, 394. http://www.trialsjournal.com/content/15/1/394. PMID:25304364.
  19. Gaugler, J. E., Yu, F., Davila, H. W., Shippee, T (2014). Alzheimer’s disease and nursing homes. Health Affair, 33, 650-657. DOI:10.1377/hlthaff.2013.1268.
  20. Watson, E.; Yu, F. (2013). Monitoring exercise delivery to increase participation adherence in older adults with Alzheimer’s disease, Journal of Gerontological Nursing, 39(5), 11-14. DOI: 10.3928/00989134-20130313- 04.* §
  21. Yu, F. (2013). Improving recruitment, retention, and adherence to 6-month cycling in Alzheimer's disease. Geriatric Nursing, 34(3), 181-6. DOI:10.1016/j.gerinurse.2012.12.014.*
  22. Yu, F., Nelson, N. W., Savik, K., Wyman, J. F., Dysken, M., Bronas, U. G. (2013). Affecting cognition and quality of life via aerobic exercise in Alzheimer’s disease, Western Journal of Nursing Research, 35(1), 24-38. DOI: 10.1177/0193945911420174. PubMed PMID: 21911546*
  23. Yu, F., Swartwood, R (2012). Feasibility and perceptions of the impact of 6-month aerobic exercise in older adults with Alzheimer’s disease, American Journal of Alzheimer’s Disease and Other Dementias, 27(6), 398-406. DOI:10.1177/1533317512453492. PubMed PMID: 22871905* §
  24. Yu, F., Savik, K., Wyman, J. F., Bronas, U. G. (2011). Maintaining physical function: A pilot study of aerobic exercise in Alzheimer’s disease, American Journal of Alzheimer’s Disease Other Dementias, 26(5) 406-412. DOI:10.1177/1533317511414861. PubMed PMID: 21750046*
  25. Yu, F. (2011). Guiding research and practice: A conceptual model for aerobic exercise training in Alzheimer’s disease, American Journal of Alzheimer’s Disease Other Dementias, 26(3), 184-194. PMID21417188. DOI: 10.1177/1533317511402317.NIHMS946686.
  26. Monsen, K. A., Sanders, A. N., Yu, F., Radosevich, D. M (2011). Comparing family home visiting outcomes for mothers with and without intellectual disabilities, Journal of Intellectual Disability Research, 55(5), 484-499.*
  27. Monsen, K. A., Westra, B. L., Oancea, S. C., Yu, F., Kerr, M. J. (2011). Linking home care interventions and hospitalization outcomes for frail and non-frail elderly patients, Research in Health and Nursing, 34(2), 160-168. NIHMS274649.*
  28. Yu, F., Leon, A., Bliss, D., Dysken, M., Savik, K., Wyman, J. F. (2011) Aerobic training for older Men with Alzheimer's disease: Individual examples of progression, Research in Gerontological Nursing, 4(4), 243-250. DOI: 10.3928/19404921-20110303-01. NIHMS946693.*
  29. Buettner, L., Yu, F., Burgener, S. (2010). Evidence supporting technology-based interventions for people with early-stage Alzheimer’s disease, Journal of Gerontological Nursing, 36(10), 15-19.
  30. Yu, F., Bil, K. (2010). Correlation between heart rate and perceived exertion during aerobic exercise in older men with Alzheimer’s disease, Nursing and Health Sciences, 12(3), 375-380. NIHMS225866. DOI: 10.1111/j.1442-2018.2010.00543.x.* §
  31. Rose, K., Yu, F., Palmer, J., Richeson, N., Burgener, S. (2010). Care considerations for persons with early onset dementia: A case studies analysis. Alzheimer’s Care Today, 11(3), 151-161.*
  32. Gaugler, J., Yu, F., Wyman, J. F., Krichbaum, K. (2009). Predictors of nursing home admission for persons with dementia, Medical Care, 47(2), 191-198.
  33.  Yu, F., Rose, K., Burgener, S., Cunningham, C., Buettner, L., Beattie, E., Bossen, A., Buckwalter, K., Fick, D., Fitzsimmons, S., Kolanowski, A., Specht, J., Richeson, N., Testad, I., McKenzie, S. (2009). Cognitive training for early-stage Alzheimer’s disease and dementia, Journal of Gerontological Nursing, 35(2), 23-30.
  34. Yu, F., Kolanowski, A. (2009). Facilitating aerobic exercise training in persons with Alzheimer's disease, Geriatric Nursing, 30(4), 250-259.*
  35. Yu, F., Ryan, L. H., Schaie, K. W., Willis, S. L., Kolanowski, A. (2009). Factors associated with cognition in adults: The Seattle Longitudinal Study, Research in Nursing and Health, 32(5), 540-550. NIHMS234604.*
  36. Monsen, K. A., Westra, B. L., Yu, F., Ramadoss, V. K., Kerr, M. J. (2009). Data management for intervention effective research: Compare deductive and inductive approaches. Research in Nursing and Health, 32,647-656.*
  37. Burgener, S., Buettner, L., Buckwalter, K., Beattie, E., Bossen, A., Fick, D., Fitzsimmons, S., Kolanowski, A., Richeson, N., Rose, K., Schreiner, A., Specht, J., Smith, M., Testad, I., Richeson, N., Yu, F., Gabrielson, M., McKenzie, S. (2008). Review of exemplar programs for adults with early-stage Alzheimer’s disease. Research in Gerontological Nursing, 1(4), 295-304.
  38. Burgener, S., Buettner, L., Buckwalter, K., Beattie, E., Bossen, A., Fick, D., Fitzsimmons, S., Kolanowski, A., Richeson, N., Rose, K., Schreiner, A., Specht, J.,Testad, I., Yu, F., McKenzie, S. (2008). Evidence supporting nutritional interventions for persons in early stage Alzheimer’s disease. Journal of Nutrition Health and Aging,12(1), 18-21.
  39. Wan, H., Yu, F., Kolanowski, A. (2008). Caring for aging Chinese: Lessons learned from the USA. Journal of Transcultural Nursing, 19, 114-120. §
  40. Yu, F., Lang, N. (2008). Using the Omaha System to examine outpatient rehabilitation problems, interventions, and outcomes between clients with and without cognitive impairment. Rehabilitation Nursing, 33(3), 124-131.*
  41. Loeb, S. J., Penrod, J., Kolanowski, A., Hupcey, J. E., Haidet, K. K., Fick, D. M., McCongle, D., Yu, F. (2008). Creating cross-disciplinary research alliances to advance nursing science. Journal of Nursing Scholarship, 40(2), 195-201.
  42. Buettner, L., Richeson, N., Yu, F., Burgener, S., Buckwalter, K., Beattie, E., Bossen, A., Fick, D., Fitzsimmons, S., Kolanowski, A., Rose, K., Schreiner, A., Specht, J., Testad, I.; McKenzie, S. (2008). Evidence supporting exercise interventions for persons in early stage Alzheimer’s disease. American Journal of Recreation Therapy, 7(1), 17-24.
  43. Penrod, J., Yu, F., Kolanowski, A., Fick, D., Loeb, S., Hupcey, J. (2007). Reframing person-centered care for persons with dementia. Research and Theory for Nursing Practice: An International Journal, 21(1), 61-76.
  44. Buettner, L., Kolanowski, A., Yu, F. (2007). Recreational games: Simple and effective cognitive stimulation programs for residents with dementia in long-term care settings. American Journal of Recreational Therapy, 6(1), 25-30.
  45. Kolanowski, A., Buettner, L., Litaker, M., Yu, F. (2006). Factors that relate to activity engagement in nursing home residents. American Journal of Alzheimer's Disease and Other Dementias, 21(1), 15-22.*
  46. Yu, F., Kolanowski, A., Strumpf, N., Eslinger, P. (2006). Improving cognition and function through exercise intervention in Alzheimer’s disease. Journal of Nursing Scholarship, 38(4), 358-365.
  47. Yu, F., Kolanowski, A., Litaker, M. (2006). The association of physical function with agitation and passivity in nursing home residents with dementia. Journal of Gerontological Nursing, 32(12), 30-36.*
  48. Yu, F., Evans, L. K., Sullivan-Marx, E. M. (2005). Functional outcomes for older adults with cognitive impairment in a comprehensive outpatient rehabilitation facility. Journal of the American Geriatrics Society, 53, 1599-1606 (Editorial commentary by Dr. Vince S. Thomas on pp 1624-1626).*
  49. Yu, F.,  Richmond, T. (2005). Factors affecting outpatient rehabilitation outcomes in elders Journal of Nursing Scholarship, 37(3), 229-236.*

Non-refereed Journal Articles, Essays, or Book Chapters

  1. Yu, F. (2017). Chapter 26 Acupressure: 26.1 Sidebar. Acupressure and Its International Appeal. Complementary Alternative Therapies in Nursing, 8 th Ed. (Editor: Ruth Lindquist). New York: Springer Publishing Company.
  2. Yu, F (2017). Chapter 4. Geriatric Assessment. Gerontological Nursing, a Bilingual Textbook, 2 nd Ed (Editor: Guifang Guo). P. R. China: People’s Medical Publishing House, the designated publisher for the Chinese Ministry of Health.
  3. Yu, F. (2016). Volume B. Behavioral management in long-term care (LTC). Encyclopedia of Adulthood and Aging (Editor: Whitbourne, S. K.). Massachusetts: John Wiley Sons, Inc.
  4. Pittaway, D., Tucker, A., Yu, F. (2015). Chapter 17. Nursing around the Globe. Choosing Nursing: From Application to Offer and Beyond (Editor: Cathy Poole). Oxon: Taylor Francis Books.
  5. Yu, F. (2014). Chapter 26 Acupressure: 26.1 Sidebar Use of Acupressure in China. Complementary  Alternative Therapies in Nursing, 7 th Ed. (Editor: Ruth Lindquist). New York: Springer Publishing Company.
  6. Yu, F. (2012). Chapter 4. Geriatric Assessment. Gerontological Nursing, a Bilingual Textbook (Editor: Guifang Guo). P. R. China: People’s Medical Publishing House, the designated publisher for the Chinese Ministry of Health. Awarded “Outstanding Textbook” in 2014 by the Ministry of Health, P. R. China.
  7. Yu, F. (2011). Analysis of the development of gerontological nursing in the U.S. and its implications for China. Chinese Nursing Management (the official journal of the Chinese Ministry of Health).
  8. Yu, F. (2008). The expatriate experience: Teaching nursing across Eastern and Western cultures (editorial commentary). Journal of Nursing Scholarship, 40(2), 184-186.
  9. Beattie, E., Bossen, A., Buckwalter, K., Buettner, L., Burgener, S., Fick, D., Fitzsimmons, S., Kolanowski, A., McKenzie, S., Richeson, N., Rose, K., Specht, J.,Yu, F. (2007). Consensus report: Review of scientific evidence addressing prevalence, documented needs, and interdisciplinary research in Persons in early stage Alzheimer’s Disease, National Alzheimer’s Association, Chicago, Illinois, January 30, 2007. http://www.alz.org/national/documents/LitReview_ne...
  10. Yu, F., Kolanowski, A. (2006). Improve function through research (editorial commentary). Journal of Gerontological Nursing, 32(12), 4-5.

Teaching

Academic Interests and Focus

Gerontological Nursing; Research, Evidence-based Practice; Science of Nursing Intervention; and AGNP specialty courses